After two seasons in a permanent engagement at the Nuremberg State Opera (2008-2010), during which Ezgi Kutlu sang roles such as Dorabella in Così fan tutte, Cherubino in Le nozze di Figaro and the Composer in Ariadne auf Naxos, her further career took her to numerous major opera houses in Europe such as the Stuttgart State Opera, Komische Oper Berlin, Frankfurt Opera, Deutsche Oper am Rhein, Opera Roma. Other engagements have included the Vlaamse Opera in Antwerp/Gent, Gran Teatre del Liceu in Barcelona, Edinburgh International Festival, Casa da Musica in Porto, Garsington Opera and the Royal Festival Hall in London with the London Philharmonic Orchestra.

Ezgi Kutlu has received her Masters from the Juilliard School of Music in New York, and the Curtis Institute of Music in Philadelphia following her studies at the Bilkent University. She attended master classes and worked with Barbara Bonney, Brigitte Eisenfeld, Marilyn Horne and Christa Ludwig. Ezgi Kutlu won prizes in competitions such as the Licia Albanese Competition and the Marian Anderson Award and was a participant in the first Young Singers Project of the 2008 Salzburg Festival.

In 2023, she made her house debut at the Grand Théâtre de Genève as Annina in Richards Strauss's Rosenkavalier. In the same year, she also returned as Juno in Barrie Kosky's production of Semele at the Komische Oper Berlin, a role for which she was also celebrated at the Opéra de Lille under the baton of Emanuelle Haim.
In the 2025/26 season, Ezgi Kutlu will sing the title role in Carmen again at the Deutsche Oper am Rhein. She will make her important role debut as Erda in Das Rheingold at the Theater Koblenz, where she had already sang Eboli in Verdi's Don Carlo the season before.